In vitro Immunotoxicology - Practical Application
نویسندگان
چکیده
منابع مشابه
Immunotoxicology: challenges in the 21st century and in vitro opportunities.
Over the last two decades, little has changed in the practice of immunotoxicity testing for regulatory purposes, especially for immunosuppression, and autoimmunity is still a challenge. Current guidelines still rely on animal tests, which include some immune endpoints in repeated dose tests and trigger dedicated tests only when certain alerts indicate a problem. At the same time, however, a wea...
متن کاملImmunotoxicology in the pharmaceutical industry.
Development of an immunotoxicology program within the pharmaceutical industry is described. With few guidelines in the area and a multitude of factors to consider, a basic screen for evaluating immune competence in species routinely used in toxicologic studies has been proposed. The future of immunotoxicology depends upon the ability of the selected immune function tests to be predictive of hum...
متن کاملFood for Thought ... Immunotoxicology: Challenges in the 21st Century and In Vitro Opportunities
Do we need yet another review on alternative methods in immunotoxicology? the authors have contributed to many that have already been published (Gennari et al., 2005; Corsini, 2006; Carfì et al., 2007; Corsini and Roggen, 2009; Galbiati et al., 2010; lankveld et al., 2010; Pfaller et al., 2010). Immunotoxicology in general is also well covered in reviews and book chapters (Descotes, 2004, 2006;...
متن کاملImmunotoxicology of beryllium lung disease.
Beryllium induces non-caseating granulomatous inflammation in humans exposed to the metal dust or fumes in both occupational and non-occupational settings. The resulting condition, chronic beryllium disease (CBD), affects principally the lungs, lymphatics, and skin and continues to plague modern industry. Beryllium exerts several important immunotoxic effects, including induction of a beryllium...
متن کاملAlterations in regulatory T-cells: rediscovered pathways in immunotoxicology.
In addition to the effector T-cells subsets, T-cells can also differentiate into cells that play a suppressive or regulatory role in adaptive immune responses. The cell types currently identified as regulatory T-cells (T(regs)) include natural or thymic-derived T(regs), T-cells which express Foxp3(+)CD25(+)CD4(+) and can suppress immune responses to autoreactive T-cells, as well as inducible T(...
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ژورنال
عنوان ژورنال: Acta Veterinaria Brno
سال: 1998
ISSN: 0001-7213,1801-7576
DOI: 10.2754/avb199867040303